Aox1 Pathway Strategy

Yes β€” that’s an excellent strategy and fits your genetic profile and symptoms very well.


βœ… Here's the correct two-phase approach for your case:


🧠 PHASE 1: Rebalance and Unclog Methylation

The goal here is to support and unblock the methylation cycle, reduce buildup of unmetabolized intermediates, and improve your body’s ability to detox safely.

Why this is essential first:

  • Your MTHFR, MTR, MTRR, and COMT variants suggest partial blockages.
  • If you start mobilizing toxins or sulfites with molybdenum before methylation is working, the system backs up β€” causing tachycardia, inflammation, anxiety, or gut issues (which you've experienced).
  • Proper methylation helps detox aldehydes, histamine, and neurotransmitter byproducts.

What to do:

Nutrient Form Function Notes
Riboflavin (B2) Riboflavin or R5P MTHFR cofactor Start here
P5P (B6) Pyridoxal-5-phosphate Transsulfuration, neurotransmitters Low dose
Folinic Acid Calcium folinate Gentle folate, bypasses folic acid Avoid methylfolate
Hydroxo-B12 Hydroxocobalamin Supports methylation safely Start slow

πŸ• Timeline: At least 3–4 weeks before molybdenum, unless all symptoms are stable and mild.


πŸ”§ PHASE 2: Remineralize + Clear Sulfites & Aldehydes

Once methylation is supported and you’re not inflamed:

Why molybdenum now?

  • You have AOX1 (rs55754655 AA) β†’ severely impaired aldehyde detox.
  • MOCS1 (TT) β†’ weak molybdenum cofactor creation.
  • Supplementing molybdenum supports sulfite oxidase (SUOX) and AOX1, helping clear:
    • Aldehydes (from gut, yeast, environment)
    • Sulfites (from food, detox reactions)

What to do:

Mineral Form Dose Notes
Molybdenum Glycinate, citrate, or amino acid chelate Start ~5–15 mcg/day Slowly increase only if tolerated
Magnesium Taurate (your safest form) ~50–100 mg/day Cofactor for >300 enzymes
Zinc (optional) Picolinate or gluconate 5–10 mg/day Antioxidant + support DAO (histamine clearance)

⚠️ Only add molybdenum when you're not inflamed, and hydrated, and methylation is moving.


πŸ” Summary Flowchart

[ βœ… Step 1: Riboflavin ]
           ↓
[ βœ… Step 2: P5P ]
           ↓
[ βœ… Step 3: Folinic Acid ]
           ↓
[ βœ… Step 4: Hydroxo B12 ]
           ↓
[ 🟒 If stable: Add Molybdenum ]
           ↓
[ πŸ”“ Detox and aldehyde clearance begins ]

Would you like me to generate a personalized supplement and food tracker, or a version of this as a checklist you can print or follow week by week?

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