✅ Here's the correct two-phase approach for your case:
🧠 PHASE 1: Rebalance and Unclog Methylation
The goal here is to support and unblock the methylation cycle, reduce buildup of unmetabolized intermediates, and improve your body’s ability to detox safely.
Why this is essential first:
- Your MTHFR, MTR, MTRR, and COMT variants suggest partial blockages.
- If you start mobilizing toxins or sulfites with molybdenum before methylation is working, the system backs up — causing tachycardia, inflammation, anxiety, or gut issues
- Proper methylation helps detox aldehydes, histamine, and neurotransmitter byproducts.
What to do:
| Nutrient | Form | Function | Notes |
|---|---|---|---|
| Riboflavin (B2) | Riboflavin or R5P | MTHFR cofactor | Start here |
| P5P (B6) | Pyridoxal-5-phosphate | Transsulfuration, neurotransmitters | Low dose |
| Folinic Acid | Calcium folinate | Gentle folate, bypasses folic acid | Avoid methylfolate |
| Hydroxo-B12 | Hydroxocobalamin | Supports methylation safely | Start slow |
🕐 Timeline: At least 3–4 weeks before molybdenum, unless all symptoms are stable and mild.
🔧 PHASE 2: Remineralize + Clear Sulfites & Aldehydes
Once methylation is supported and you’re not inflamed:
Why molybdenum now?
- You have AOX1 (rs55754655 AA) → severely impaired aldehyde detox.
- MOCS1 (TT) → weak molybdenum cofactor creation.
- Supplementing molybdenum supports sulfite oxidase (SUOX) and AOX1, helping clear:
- Aldehydes (from gut, yeast, environment)
- Sulfites (from food, detox reactions)
What to do:
| Mineral | Form | Dose | Notes |
|---|---|---|---|
| Molybdenum | Glycinate, citrate, or amino acid chelate | Start ~5–15 mcg/day | Slowly increase only if tolerated |
| Magnesium | Taurate (your safest form) | ~50–100 mg/day | Cofactor for >300 enzymes |
| Zinc (optional) | Picolinate or gluconate | 5–10 mg/day | Antioxidant + support DAO (histamine clearance) |
⚠️ Only add molybdenum when you're not inflamed, and hydrated, and methylation is moving.
🔁 Summary Flowchart
[ ✅ Step 1: Riboflavin ]
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[ ✅ Step 2: P5P ]
↓
[ ✅ Step 3: Folinic Acid ]
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[ ✅ Step 4: Hydroxo B12 ]
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[ 🟢 If stable: Add Molybdenum ]
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[ 🔓 Detox and aldehyde clearance begins ]